Switching the H-bonding network of a foldamer by modulating the backbone chirality and constitutional ratio of amino acids.

نویسندگان

  • Veera V E Ramesh
  • Kuruppanthara N Vijayadas
  • Snehal Dhokale
  • Rajesh G Gonnade
  • Pattuparambil R Rajamohanan
  • Gangadhar J Sanjayan
چکیده

This communication describes the folding propensity of a heterofoldamer motif featuring proline (Pro) and anthranilic acid (Ant) residues in a 1:2:1 (α:β:α) constitutional ratio. Structural investigations unequivocally suggest that the hydrogen-bonding network of this foldamer motif can be switched between 9-membered and 6-membered by modulating the backbone chirality and constitutional ratio of the amino acid residues.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 11 41  شماره 

صفحات  -

تاریخ انتشار 2013